A Phase Ib, First-In-Human, Dose Escalation and Expansion, Multicenter Study of XMT-1660 in Participants with Solid Tumors
Details
A Study of XMT-1660 in Solid Tumors
Eligibility
You can join if...
Inclusion Criteria
-Participants must be at least 18 years of age
-Participant has proven recurrent or advanced solid tumor and has disease progression
after treatment with available anti-cancer therapies known to confer benefit or is
intolerant to treatment
-Participant must be willing to undergo a minimally invasive tumor biopsy to obtain tumor
tissue for local testing, if medically feasible, prior to C1D1.
Exclusion Criteria
-Participant has received prior treatment with another ADC containing an auristatin or
maytansinoid payload (e.g., mirvetuxuximab)
-Major surgery within 28 days of starting study treatment, systemic anticancer therapy within the time period of 28 days or 5 half-lives of the prior therapy before starting study treatment (14 days or 5 half-lives for small molecule targeted therapy), whichever is less, or palliative radiation therapy within 14 days of starting study treatment.
-Participants with human immunodeficiency virus (HIV) infection are excluded from
study entry. An HIV test is required during Screening