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BA3011 Alone & in Combinationw/Nivolumab in Adult Patientsw/Met on a PD-1/L1, EGFR, or ALK Inhibitor

Misako Nagasaka


A Study On:

  • Lung

Status:

Eligibility

Adult

Interested in joining this trial?

Official Title

A Phase II Study of Mecbotamab Vedotin (BA3011) Alone and in Combination with Nivolumab in Adult Patients with Metastatic Non-Small Cell Lung Cancer Who Had Prior Disease Progression On or Are Intolerant to a PD-1/L1, EGFR, or ALK Inhibitor

Details

The objective of this study is to assess safety and efficacy of CAB-AXL-ADC in NSCLC.


Eligibility

You can join if...

You need to have the following exams, tests or procedures to find out if you can be in the study:

  • You will be asked about your health history including any surgeries you've had and the treatments you've received for your cancer.
  • Complete physical exam
  • Performance status assessment, to see how able you are to perform your daily activities.
  • Measurement of your height and weight
  • Vital sign measurements, including blood pressure, heart rate, breathing (respiratory) rate, and body temperature.
  • Routine blood tests [about 13 mL or 2 ½ teaspoons of blood (in total)] to test your:
  • blood counts (white blood cells, red blood cells, etc.),
  • liver, kidney, and thyroid function,
  • cholesterol while fasting (no food within 6 hours),
  • blood clotting ability.
  • Blood test [about 1.5 mL or ¼ teaspoon of blood] for specific viruses, including hepatitis B and hepatitis C, and HIV. If you have positive test results for HIV or Hepatitis B or C, we will notify you. We are required to notify state health authorities of positive results.
  • Routine urine testing
  • Blood or urine test for pregnancy, if you are a woman who is capable of childbearing (unless you have had a hysterectomy or your tubes tied, or you are in menopause and your last menstrual period was at least 1 year ago).
  • Evaluation of the location and size of your cancer will be performed.
  • Your doctor may use different types of imaging, such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), clinical exam or some combination of these tests.
  • Electrocardiogram (ECG): a test that measures the electrical activity of your heart by using electrodes placed on your body. This assessment is not invasive which means that it does not involve the introduction of instruments or other objects into the body or body cavities.
    -You will be asked about all medications (including over-the-counter and herbal remedies) you are taking and have taken in the past month.
  • You will be asked to describe any symptoms you are currently experiencing.

Get in touch with our study team