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Light Therapy for PD (NN110)

NICOLAS PHIELIPP


A Study On:

  • Parkinson Disease
  • Brain - Neurologic/ Psychologic

Status:

  • Open

Eligibility

We are seeking participants who have been diagnosed with Parkinson's Disease and have sleep problems. Participants must also be at least 45 years of age. The trial is being conducted at 25 sites nationwide.

Interested in joining this trial?

Official Title

A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson s Disease (NN110)

Details

The purpose of the research study is to learn if Light Therapy reduces sleep problems associated with Parkinson's Disease and improves quality of life. As part of this study, we will use a number of assessments and questionnaires to determine if Light Therapy improves sleep problems in individuals with Parkinson's Disease.


Eligibility

You can join if...

Inclusion Criteria:

  1. Diagnosis of idiopathic PD as defined by the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease;
  2. PD Hoehn and Yahr stage 2-4;
  3. A score of 2 (mild) or above on the Sleep Problems question of the MDS-UPDRS Part 1;
  4. Stable dose of all PD medications for at least 30 days prior to randomization;
  5. Willingness to wear an Actiwatch and complete daily sleep logs;
  6. Age 45 or above

Exclusion Criteria:

  1. Atypical or secondary forms of parkinsonism;
  2. Co-existent significant sleep apnea at screening, as determined by the PI's clinical assessment; adequately treated sleep apnea, as assessed by sleep apnea machine download (CPAP download) will be permitted;
  3. Co-existent symptomatic restless legs syndrome (RLS) (as assessed by the International Classification of Sleep Disorders (ICDS) diagnostic criteria for RLS) at screening;
    Cognitive impairment as determined by a Mini Mental State Examination score <25 at screening;
  4. Presence of moderate depression defined as a Beck Depression Inventory II (BDI-II) score ≥20 at screening;
  5. Current untreated hallucinations or psychosis (drug-induced or spontaneous) with a score of 2 or above on the Hallucinations and Psychosis question of the MDS-UPDRS Part 2;
  6. Use of hypno-sedative drugs for sleep or stimulants, unless the participant has been on a stable dose for at least 60 days prior to the screening;
  7. Ongoing or recent (within 30 days prior to screening) Cognitive Behavioral Therapy for Insomnia;
  8. Use of antidepressants, unless the participant has been on a stable dose for at least 60 days prior to the screening;
  9. Work hours between 10 PM and 6 AM, within 60 days prior to randomization or anticipated during the 16 weeks after screening;
  10. Travel between 3 or more time zones within 45 days prior to study screening or anticipated such travel during the 16 weeks after screening;
  11. Unstable or serious medical illness;
  12. History of significant eye trauma or disease, retinopathy, or cataract Grade 4 that would significantly affect transmission or processing of light through either eye;
  13. Current use, use at any time during study participation, or use within the 30 days prior to screening of photosensitizing or other medications that in the opinion of the investigator would interfere with the safety of the participant during the trial, including: amiodarone, porfimer, psoralens, chlorpromazine, quinidine, demeclocycline, temoporfin, tetracycline, fleroxacin, oral isoretinoin, voriconazole, nalidixic acid, thioridazine, St. John's wort, ofloxacin, and piroxicam;
  14. Pregnant women will be excluded from participation; if a participant is pre-menopausal, a urine pregnancy test will be conducted at randomization to determine eligibility.

Get in touch with our study team